Anaesthetic Management of a Paediatric Case of G6pd Deficiency Posted for Craniotomy
DOI:
https://doi.org/10.4103/kaj/2019/v17i1-2/153095Keywords:
Glucose-6-Phosphate, Haemolysis, Neuroanaesthesia.Abstract
Glucose-6-Phosphate Dehydrogenase deficiency is an inherited X-linked enzymatic disorder that results in haemolytic anaemia whenever the body faces oxidative stress in circumstances such as drug interactions (including anaesthetic agents), infections and surgical stress. A complete pre-anaesthetic evaluation, thorough planning of anaesthetic technique and adequate monitoring helps avoid oxidative stress in the perioperative period. The authors report the successful management of a 9-month old with G6PD deficiency who underwent craniotomy with no acute or delayed complications of the condition.Downloads
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Dogra N, Puri GD, Rana SS. Glucose-6-phosphate dehydrogenase deficiency and cardiac surgery. Perfusion, 2010; 25:417-421. https://doi.org/10.1177/0267659110380770. PMid:20705643.
Luzzatto L, Metha A, Vulliany T. Glucose-6-Phosphate Dehydrogenase Deficiency. In: Scriver CR, Beaudet AL, Sly WS, et al, Eds. 2001; 8:4517-4553. https://doi.org/10.1006/rwgn.2001.1520.
Xu DD, Wen FQ, Lv RY, Zhang M, Chen YS. Gene promoter methylation in glucose-6-phosphate dehydrogenase deficiency. Zhongguo Dang Dai Er Ke Za Zhi, 2016; 18:405-409.
Youngster I, Arcavi L, Schechmaster R, Akayzen Y, Popliski H, Shimonov J, et al. Medications and glucose-6-phosphate dehydrogenase deficiency: an evidence-based review. Drug Saf, 2010; 33:713-726. https://doi.org/10.2165/11536520-000000000-00000. PMid:20701405.
Habibi B, Basty R, Chodez S, Prunat A. Thiopentone related immune hemolytic anemia and renal failure. Specific Involvement of Red Cell Antigen 1. N. Engl. J. Med., 1985; 312:353-355. https://doi.org/10.1056/NEJM198502073120606. PMid:3969087.
Valiaveedan S, Mahajan C, Rath GP, Bindra A, Marda MK. Anaesthetic management in patients with glucose-6-phosphate dehydrogenase deficiency undergoing neurosurgical procedures. Indian J. Anaesth., 2011; 55:68-70. https://doi.org/10.4103/0019-5049.76597. PMid:21431058 PMCid:PMC3057251.
Schwartz JP, Cooperberg AA, Rosenberg A. Platelet function studies in patients with glucose-6-phosphate dehydrogenase deficiency. Br. J. Haematol. 1974; 27:273-280. https://doi.org/10.1111/j.1365-2141.1974.tb06793.x. PMid:4843674.
Dogra N, Puri GD, Rana SS. Glucose-6-phosphate dehydrogenase deficiency and cardiac surgery. Perfusion, 2010; 25:417-421. https://doi.org/10.1177/0267659110380770. PMid:20705643.
Petz LD, Garratty G. Immune haemolytic anemias. 2nd Ed. Philadelphia: Churchill Livingstone; 2004. p. 261-317. https://doi.org/10.1016/B978-0-443-08559-8.50012-1.
Quereshy FA, Gold ES, Powers MP. Hemolytic anemia in a glucose-6-phosphate dehydrogenase-deficient patient triggered by a maxillofacial infection. J. Oral. Maxillofac. Surg., 2000; 58:805-807. https://doi.org/10.1053/joms.2000.7273. PMid:10883698.
Cappellini MD, Fiorelli G. Glucose-6-phosphate dehydrogenas deficiency. Lancet, 2008; 371:64-74. https://doi.org/10.1016/S0140-6736(08)60073-2.
Edwards CQ. Anemia and the liver. Hepatobiliary manifestations of anemia. Clin Liver Dis., 2002; 6:891-907. https://doi.org/10.1016/S1089-3261(02)00050-8.